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U.S. National Institutes of Health
Last Updated: 10/08/12

MRTB — Goals

MRTB’s goals are:

  • Establish a site-disease specific forum for Radiation Oncologists to discuss and initiate clinical trials using agents within or outside CTEP portfolio.
  • Establish radiation biology focus groups to set a national standards on screening assay systems using in-vitro as well as in-vivo approaches.
  • To provide complete support in generating pre-clinical data for using in-vitro (NCI 60 cell line screening, clonogenic assays and apoptotic assays) and in-vivo approaches (orthotopic model with either syngenic or xenograft tumors, flank xenografts and GEMMS).
  • To perform correlative studies using samples obtained from CTEP approved radiation clinical trials.
  • To establish Web-based radiation biology database for agents screened by in-vivo and in-vitro approaches.
  • Organize workshops and seminars among the focus groups.
  • Provide resource education in molecular radiation oncology for residents in radiation oncology, medical oncology and surgical oncology.
  • Provide laboratory skills radiation biology training for clinicians, residents, post-docs and students from all over the world.
Chart illustrating the goals of the MRTB