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U.S. National Institutes of Health
Last Updated: 10/08/12

MRTB — Mission

The primary mission of the MRTB is to facilitate the generation of preclinical data that will support clinical trials with radiation modifiers. The program that was first initiated was called the RAdiation Modifiers Evaluation Module (RAMEM) which was an unique national and international resource to assist a wide range of potential collaborators in providing preclinical data to support the safe conduct of drug approval for clinical trials involving radiation modifiers. Adopting such concepts, currently MRTB plays a central role developing the overall design for clinical implementation of radiation modifiers coupled with updates on advances in approaches, particularly, in molecular targeted therapy.

Selection of Molecular Targeted Agents as Potential Radiation Sensitizers Based on Mechanisms of Action